Spontaneous fibrinolysis in pulmonary embolism.

Catheter-directed Therapies for Acute Pulmonary Embolism: It is Time to Establish a Role

Acute pulmonary embolism (PE) is associated with a broad spectrum of clinical severity. However, despite the varying presentations, therapy is primarily limited to anticoagulation. The only widely accepted exception to the use of anticoagulation alone is in those patients with massive acute PE, in whom systemic fibrinolysis is generally considered the most appropriate option. Unfortunately, the...

[Thrombus in transit and submassive pulmonary thromboembolism succesfully treated with tenecteplase].

Right heart thrombus is a slightly detectable condition. In patients presenting with acute pulmonary embolism, the finding of thrombus in transit has been associated with high in-hospital mortality. We present a case of a 50-year-old male patient with acute pulmonary embolism and a thrombus in transit in the right atrium. We took the decision to perform fibrinolysis with tenecteplase, presentin...

Neurologically normal survival after fibrinolysis during prolonged cardiac arrest: case report and discussion.

Cardiac arrest secondary to pulmonary embolism is a devastating condition with a high mortality rate. It is currently unclear whether fibrinolysis (thrombolysis) is beneficial in this setting. We report the case of a 28-year-old woman with a pulmonary embolism who developed return of pulses following the administration of tissue plasminogen activator after 38 minutes of pulseless electrical act...

Reperfusion therapy in out-of-hospital cardiac arrest: current insights.

Although early care in out-of-hospital cardiac arrest has been improved over the past decades, survival remains poor and neurological performance after survival is often impaired. Consequently, new therapies are needed to improve outcome. As thrombotic processes such as acute myocardial infarction or pulmonary embolism are frequent causes of cardiac arrest, therapies like fibrinolysis or percut...

Fibrinolysis for Intermediate-Risk Pulmonary Embolism